Tetramelic, symmetrical limb reduction, radial defects, Oligodactyly or Syndactyly, charecteristic Facies Wit Hypertelorism, cleft lip or and cleft palate, prominent Premaxilla, simple low set ears. Other features include pre and postnatal growth retardation, corneal clouding, delayed permanent tooth eruption, variable brain formations, renal and heart defects, Hypogonadism, early death in severely affected patients. Survivors reported with mental retardation of all degrees, but normal intellect also reported.